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College football expert picks for Week 13, including predicting the winners of Ohio State-Michigan, Oklahoma-Oklahoma State, and Auburn-Alabama.

It’s rivalry week in college football, and this one might have the most impactful games in the Playoff era. Carve yourself a nice piece of sweet potato pie, grab a seat, and prepare for some intense action this week.

The Egg Bowl pits Ole Miss against Mississippi State on Thanksgiving day. It will be the only ranked game and it’s on primetime. You know Lane Kiffin will have something special cooked up for Arch Manning.

On Friday and Saturday, the ACC Atlantic could fall into No. 23 Clemson‘s lap as they travel to Columbia to face the Gamecocks. But that’s only if No. 20 NC State loses to rival UNC and No. 18 Wake Forest trips up against a resurgent Boston College team.

But enough of the appetizers. This week’s main courses come on Saturday. Ohio State takes on Michigan in one of the most important installments in The Game in recent years. On the heels of that comes the Iron Bowl, where Auburn hopes to play spoiler to Alabama’s Playoff bid. Finally, Oklahoma and Oklahoma State duke it out to decide which team keeps their distance hopes for a Playoff spot alive.

It will be a day of tension thicker than cold gravy. My oh my. Let’s do this.

College football expert picks for Week 13’s Top 25 games

Thursday, November 25

  • No. 9 Ole Miss at Mississippi State — 7:30 p.m. ET — ESPN

Friday, November 26

  • Boise State at No. 21 San Diego State — 12 p.m. ET — CBS
  • No. 16 Iowa at Nebraska — 1:30 p.m. ET — BTN
  • No. 4 Cincinnati at East Carolina — 3:30 p.m. ET — ABC
  • Missouri at No. 25 Arkansas — 3:30 p.m. ET — CBS
  • Colorado at No. 19 Utah — 4 p.m. ET — FOX
  • North Carolina at No. 20 NC State — 7 p.m. ET — ESPN

Saturday, November 27

  • No. 1 Georgia at Georgia Tech — 12 p.m. ET — ABC
  • No. 2 Ohio State at No. 5 Michigan — 12 p.m. ET — FOX
  • Texas Tech at No. 8 Baylor — 12 p.m. ET — FS1
  • No. 18 Wake Forest at Boston College — 12 p.m. ET — ESPN2
  • No. 24 Houston at UConn — 12 p.m. ET — CBSSN
  • No. 22 UTSA at North Texas — 2 p.m. ET — ESPN+
  • No. 3 Alabama at Auburn — 3:30 p.m. ET — CBS
  • Oregon State at No. 11 Oregon — 3:30 p.m. ET — ESPN
  • Penn State at No. 12 Michigan State — 3:30 p.m. ET — ABC
  • No. 14 Wisconsin at Minnesota — 4 p.m. ET — FOX
  • No. 15 Texas A&M at LSU — 7 p.m. ET — ESPN
  • No. 10 Oklahoma at No. 7 Oklahoma State — 7:30 p.m. ET — ABC
  • No. 17 Pittsburg at Syracuse — 7:30 p.m. ET — ACCN
  • No. 23 Clemson at South Carolina — 7:30 p.m. ET — SECN
  • No. 6 Notre Dame at Stanford — 8 p.m. ET — FOX
  • No. 13 BYU at USC — 10:30 p.m. ET — ESPN

The Mayhem Pick (2-2) this week is Michigan over Ohio State. It isn’t because this one is the most likely upset, that goes to Oklahoma spoiling Oklahoma State’s season. No. This one is because it will absolutely destroy the current hierarchy in the CFP rankings and all but ensure we don’t get to see Ohio State’s offense versus Georgia’s defense. In the year of our Lord 2021, we don’t get to have nice things.

Next:25 best college football stadiums to watch a game

For more NCAA football news, analysis, opinion and unique coverage by FanSided, including Heisman Trophy and College Football Playoff rankings, be sure to bookmark these pages.

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FDA endorses Merck COVID pill, paving way for US authorization of 1st at-home drug for virus

WASHINGTON -- A panel of U.S. health advisers on Tuesday narrowly backed the benefits of a closely watched COVID-19 pill from Merck, setting the stage for a likely authorization of the first drug that Americans could take at home to treat the virus.

A Food and Drug Administration panel voted 13-10 that the drug's benefits outweigh its risks, including potential birth defects if used during pregnancy.

The group's recommendation came after hours of debate about the drug's modest benefits and potential safety issues. Experts backing the treatment stressed it should not be used by pregnant women and called on FDA to recommend extra precautions, including pregnancy tests for women before using the drug.

The group's vote specifically backed the drug for adults with mild-to-moderate COVID-19 who face the greatest risks, including those with conditions like obesity, asthma and old age.

The FDA isn't bound by the panel's recommendation and is expected to make its own decision before year's end.

FDA authorization for the drug, molnupiravir, could be a major step in treating the virus. It would give doctors the first drug they could prescribe for patients to take on their own, easing the burden on hospitals and helping to curb deaths.

The pill is already authorized in the U.K.

RELATED: Pfizer to allow broader global access to its experimental COVID-19 antiviral pill



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